In the case of the Metal Mohawk, it actually was difficult for the owner to maintain. He kept bumping the spikes on things and eventually had them removed. Granted, his was a cosmetic change and not a functional one. I would be willing to put up with extra care to effectively replace a hand.
Additionally, consider that people who receive donor transplants will use immune suppressants for the remainder of their life.
That said, material selection is also important.